Welcome to the Jemielity Group

Welcome at the website of Jacek Jemielity Group at Centre of New Technologies and the Division of Biophysics, Faculty of Physics, University of Warsaw. Our group is interested in the chemical synthesis, properties and applications of modified nucleotides and nucleic acids. Our research encompasses improving methods for the chemical synthesis of nucleotide analogs, designing new modified nucleotides as tools for molecular biology and conjugating nucleotides to labels, tags and new materials. One of our particular interests, is development of eukaryotic mRNA cap analogs with potential medicinal applications.


Recent News

Adam won silver medal in “Golden Medal” competition

Adam Mamot has been awarded with the second prize in "Golden Medal of Chemistry" competition for best bachelor...

Congratulations to Jakub!

Jakub Dabrowski  defended his M. Sc thesis at Faculty of Physics University of Warsaw. Congratulations!!!

3 students graduated in September

September is the month of graduations: Sylwia Bednarek and Mateusz Kozarski defended, respectively, M. Sc and B.Sc. theses...


News archive

Research

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Synthesis and applications of phosphate-modified nucleotides
mRNA cap analogs for the preparation of chemically engineered mRNAs
Cap analog-based inhibitors of protein biosynthesis
Nucleotide labeling, conjugation and immobilization

Molecular Collection

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Mononucleotide mRNA cap analogs with unmodified (oligo)phosphate moiety
Mononucleotide mRNA cap analogs with modified (oligo)phosphate moiety
enzymatically resistant inhibitors or translation
Reagent for the preparation of mRNAs with enhanced stability and translation efficiency β-S-ARCA

mRNA biotinylation

Recent Publications

Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential

By Malwina Strenkowska, Renata Grzela, Maciej Majewski, Katarzyna Wnek, Joanna Kowalska, Maciej Lukaszewicz, Joanna Zuberek, Edward Darzynkiewicz, Andreas N Kuhn, Ugur Sahin, Jacek Jemielity,

Published in Nucleic Acids Research 44 (2016) 9578-9590

Structural basis of mRNA-cap recognition by Dcp1–Dcp2

By Jeffrey S. Mugridge, Marcin Ziemniak, Jacek Jemielity, John D. Gross,

Published in Nature Structural & Molecular Biology 23 (2016) 987–994

A novel route for preparing 5′ cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry

By Sylwia Walczak, Anna Nowicka, Dorota Kubacka, Kaja Fac, Przemyslaw Wanat, Seweryn Mroczek, Joanna Kowalska, Jacek Jemielity,

Published in Chemical Science 7 (2016) DOI: 10.1039/C6SC02437H


Publications archive