Welcome to the Jemielity Group

Welcome at the website of Jacek Jemielity Group at Centre of New Technologies and the Division of Biophysics, Faculty of Physics, University of Warsaw. Our group is interested in the chemical synthesis, properties and applications of modified nucleotides and nucleic acids. Our research encompasses improving methods for the chemical synthesis of nucleotide analogs, designing new modified nucleotides as tools for molecular biology and conjugating nucleotides to labels, tags and new materials. One of our particular interests, is development of eukaryotic mRNA cap analogs with potential medicinal applications.


Recent News

Congrats to Sylwia, Ph.D.!

Sylwia Ciechanowicz (p. Walczak) successfully defended her PhD thesis today. Congrats Dr Sylwia!!

Michał and Piotr joined our group

We have a new lab technician - Michał and a new Ph.D. student - Piotr. Welcome on...

Sholarship of Minister of Science and Higher Education for Dominika and Radosław

Our students, Dominika Strzelecka and Radosław Wójcik, have been awarded the Ministry of Science and Higher Education Scholarships for...


News archive

Research

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Synthesis and applications of phosphate-modified nucleotides
mRNA cap analogs for the preparation of chemically engineered mRNAs
Cap analog-based inhibitors of protein biosynthesis
Nucleotide labeling, conjugation and immobilization

Molecular Collection


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Mononucleotide mRNA cap analogs with unmodified (oligo)phosphate moiety
Mononucleotide mRNA cap analogs with modified (oligo)phosphate moiety
enzymatically resistant inhibitors or translation
Reagent for the preparation of mRNAs with enhanced stability and translation efficiency β-S-ARCA

Recent Publications

Fluorescent turn-on probes for the development of binding and hydrolytic activity assays for mRNA cap-recognising proteins

By Renata Kasprzyk, Beata Jagoda Starek, Sylwia Ciechanowicz, Dorota Kubacka, Joanna Kowalska, Jacek Jemielity,

Published in Chemistry - A European Journal (2019)

Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs

By Agnieszka Młynarska-Cieślak, Anais Depaix, Ewa Grudzień-Nogalska, Paweł J. Sikorski, Marcin Warmiński, Megerditch Kiledjian, Jacek Jemielity, Joanna Kowalska,

Published in Organic Letters 20 (2018) 7650–7655

mRNAs biotinylated within the 5′ cap and protected against decapping: new tools to capture RNA–protein complexes

By Sylwia Bednarek, Vanesa Madan, Paweł J. Sikorski, Ralf Bartenschlager, Joanna Kowalska, Jacek Jemielity,

Published in Philosophical Transactions of The Royal Society B 373 (2018)


Publications archive