Welcome to the Jemielity Group

Welcome at the website of Jacek Jemielity Group at Centre of New Technologies and the Division of Biophysics, Faculty of Physics, University of Warsaw. Our group is interested in the chemical synthesis, properties and applications of modified nucleotides and nucleic acids. Our research encompasses improving methods for the chemical synthesis of nucleotide analogs, designing new modified nucleotides as tools for molecular biology and conjugating nucleotides to labels, tags and new materials. One of our particular interests, is development of eukaryotic mRNA cap analogs with potential medicinal applications.

Recent News

Congrats to Marcin, Ph.D.!

Marcin Warmiński successfully defended his PhD...

NCN grants for Asia and Paweł

Paweł and Asia have been awarded with SONATA and OPUS grants. Great job guys!

Congrats to Sylwia, Ph.D.!

Sylwia Ciechanowicz (p. Walczak) successfully defended her PhD thesis today. Congrats Dr Sylwia!!

News archive


Synthesis and applications of phosphate-modified nucleotides
mRNA cap analogs for the preparation of chemically engineered mRNAs
Cap analog-based inhibitors of protein biosynthesis
Nucleotide labeling, conjugation and immobilization

Molecular Collection

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Mononucleotide mRNA cap analogs with unmodified (oligo)phosphate moiety
Mononucleotide mRNA cap analogs with modified (oligo)phosphate moiety
enzymatically resistant inhibitors or translation
Reagent for the preparation of mRNAs with enhanced stability and translation efficiency β-S-ARCA

Recent Publications

N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, Reactivity, and Applications to the Study of Cap-Binding Proteins

By Michał Kopciał, Błażej A. Wojtczak, Renata Kasprzyk, Joanna Kowalska, Jacek Jemielity,

Published in Molecules 24 (2019)

Fluorescent turn-on probes for the development of binding and hydrolytic activity assays for mRNA cap-recognising proteins

By Renata Kasprzyk, Beata Jagoda Starek, Sylwia Ciechanowicz, Dorota Kubacka, Joanna Kowalska, Jacek Jemielity,

Published in Chemistry - A European Journal (2019)

Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs

By Agnieszka Młynarska-Cieślak, Anais Depaix, Ewa Grudzień-Nogalska, Paweł J. Sikorski, Marcin Warmiński, Megerditch Kiledjian, Jacek Jemielity, Joanna Kowalska,

Published in Organic Letters 20 (2018) 7650–7655

Publications archive