Welcome to the Jemielity Group

Welcome at the website of Jacek Jemielity Group at Centre of New Technologies and the Division of Biophysics, Faculty of Physics, University of Warsaw. Our group is interested in the chemical synthesis, properties and applications of modified nucleotides and nucleic acids. Our research encompasses improving methods for the chemical synthesis of nucleotide analogs, designing new modified nucleotides as tools for molecular biology and conjugating nucleotides to labels, tags and new materials. One of our particular interests, is development of eukaryotic mRNA cap analogs with potential medicinal applications.


Recent News

PhD student wanted

We are looking for candidates to fill PhD student research position in a bioorganic chemistry-oriented research project, available from...

Welcome to Poland Anaïs!

We warmly welcome our newest team member, Anaïs Depaix.  Anaïs joined our team as a post-doc and will be...

SONATA Grant for Błażej

Błażej Wojtczak has been awarded NCN SONATA  grant to develop new trimethylguanosine cap analogues as tools to study...


News archive

Research

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Synthesis and applications of phosphate-modified nucleotides
mRNA cap analogs for the preparation of chemically engineered mRNAs
Cap analog-based inhibitors of protein biosynthesis
Nucleotide labeling, conjugation and immobilization

Molecular Collection


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Mononucleotide mRNA cap analogs with unmodified (oligo)phosphate moiety
Mononucleotide mRNA cap analogs with modified (oligo)phosphate moiety
enzymatically resistant inhibitors or translation
Reagent for the preparation of mRNAs with enhanced stability and translation efficiency β-S-ARCA

Recent Publications

5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes

By Błażej A. Wojtczak, Paweł J. Sikorski, Kaja Fac-Dąbrowska, Anna Nowicka, Marcin Warmiński, Dorota Kubacka, Elżbieta Nowak, Marcin Nowotny, Joanna Kowalska, Jacek Jemielity,

Published in Journal of the American Chemical Society 140 (2018) 5987-5999

Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis

By JS Mugridge, RW Tibble, M Ziemniak, J Jemielity, JD Gross,

Published in Nature communications 9 (2018) 1152

7-Methylguanosine monophosphate analogues with 5′-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase

By Mateusz Kozarski, Dorota Kubacka, Błażej A. Wojtczak, Renata Kasprzyk, Marek Baranowski, Joanna Kowalska,

Published in Bioorganic & Medicinal Chemistry 26 (2018) 191-199


Publications archive