Welcome to the Jemielity Group

Welcome at the website of Jacek Jemielity Group at Centre of New Technologies and the Division of Biophysics, Faculty of Physics, University of Warsaw. Our group is interested in the chemical synthesis, properties and applications of modified nucleotides and nucleic acids. Our research encompasses improving methods for the chemical synthesis of nucleotide analogs, designing new modified nucleotides as tools for molecular biology and conjugating nucleotides to labels, tags and new materials. One of our particular interests, is development of eukaryotic mRNA cap analogs with potential medicinal applications.


Recent News

PhD student wanted

We are looking for candidates to fill PhD student research position in a bioorganic chemistry-oriented research project. More information...

ETIUDA for Przemek!

Przemysław Wanat has been awarded with NCN ETIUDA grant. The project includes internship in Tom Brown's Lab in Oxford,...

Congrats to Ania and Błażej

Congratulations to Ania and Błażej who got married this weekend!!! All the best in new way of your life!!!


News archive

Research

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Synthesis and applications of phosphate-modified nucleotides
mRNA cap analogs for the preparation of chemically engineered mRNAs
Cap analog-based inhibitors of protein biosynthesis
Nucleotide labeling, conjugation and immobilization

Molecular Collection


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Mononucleotide mRNA cap analogs with unmodified (oligo)phosphate moiety
Mononucleotide mRNA cap analogs with modified (oligo)phosphate moiety
enzymatically resistant inhibitors or translation
Reagent for the preparation of mRNAs with enhanced stability and translation efficiency β-S-ARCA

Recent Publications

Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs

By Agnieszka Młynarska-Cieślak, Anais Depaix, Ewa Grudzień-Nogalska, Paweł J. Sikorski, Marcin Warmiński, Megerditch Kiledjian, Jacek Jemielity, Joanna Kowalska,

Published in Organic Letters (2018)

mRNAs biotinylated within the 5′ cap and protected against decapping: new tools to capture RNA–protein complexes

By Sylwia Bednarek, Vanesa Madan, Paweł J. Sikorski, Ralf Bartenschlager, Joanna Kowalska, Jacek Jemielity,

Published in Philosophical Transactions of The Royal Society B 373 (2018)

Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation

By Katharina Essig, Nina Kronbeck, Joao C. Guimaraes, Claudia Lohs, Andreas Schlundt, Anne Hoffmann, Gesine Behrens, Sven Brenner, Joanna Kowalska, Cristina Lopez-Rodriguez, Jacek Jemielity, Helmut Holtmann, Kristin Reiche, Jörg Hackermüller, Michael Sattler, Mihaela Zavolan , Vigo Heissmeyer,

Published in Nature Communications 9 (2018) 3810


Publications archive