Welcome to the Jemielity Group

Welcome at the website of Jacek Jemielity Group at Centre of New Technologies and the Division of Biophysics, Faculty of Physics, University of Warsaw. Our group is interested in the chemical synthesis, properties and applications of modified nucleotides and nucleic acids. Our research encompasses improving methods for the chemical synthesis of nucleotide analogs, designing new modified nucleotides as tools for molecular biology and conjugating nucleotides to labels, tags and new materials. One of our particular interests, is development of eukaryotic mRNA cap analogs with potential medicinal applications.


Recent News

PhD student wanted

We are looking for candidate to fill PhD student position in a bioorganic chemistry field research project. More information...

Asia’s Habilitation

Sincere congratulations to Joanna Kowalska, whom the Council of Chemical Sciences at the University of Warsaw awarded the habilitation...

Farewell

Recently we have said goodbye to 3 members of our group - Natalia and Tomek - our former post-docs,...


News archive

Research

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Synthesis and applications of phosphate-modified nucleotides
mRNA cap analogs for the preparation of chemically engineered mRNAs
Cap analog-based inhibitors of protein biosynthesis
Nucleotide labeling, conjugation and immobilization

Molecular Collection

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Mononucleotide mRNA cap analogs with unmodified (oligo)phosphate moiety
Mononucleotide mRNA cap analogs with modified (oligo)phosphate moiety
enzymatically resistant inhibitors or translation
Reagent for the preparation of mRNAs with enhanced stability and translation efficiency β-S-ARCA

mRNA biotinylation

Recent Publications

DXO/Rai1 enzymes remove 5′-end FAD and dephospho-CoA caps on RNAs

By Selom K. Doamekpor, Ewa Grudzień-Nogalska, Agnieszka Młynarska-Cieślak, Joanna Kowalska, Megerditch Kiledjian, Liang Tong,

Published in Nucleic Acids Research (2020)

Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation

By Sebastian Gołojuch, Michał Kopciał, Dominika Strzelecka, Renata Kasprzyk, Natalia Baran, Paweł J. Sikorski, Joanna Kowalska, Jacek Jemielity,

Published in Bioorganic & Medicinal Chemistry (2020)

Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity

By Renata Kasprzyk, Mateusz Fido, Adam Mamot, Przemysław Wanat, Mirosław Śmietański, Michał Kopciał, Victoria Cowling, Joanna Kowalska, Jacek Jemielity,

Published in Chemistry - A European Journal (2020)


Publications archive