Publications Archive


Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation

By Katharina Essig, Nina Kronbeck, Joao C. Guimaraes, Claudia Lohs, Andreas Schlundt, Anne Hoffmann, Gesine Behrens, Sven Brenner, Joanna Kowalska, Cristina Lopez-Rodriguez, Jacek Jemielity, Helmut Holtmann, Kristin Reiche, Jörg Hackermüller, Michael Sattler, Mihaela Zavolan , Vigo Heissmeyer,

Published in Nature Communications 9 (2018) 3810

Exploring the potential of phosphotriazole 5′ mRNA cap analogues as efficient translation initiators

By Sylwia Walczak, Paweł Sikorski, Renata Kasprzyk, Joanna Kowalska, Jacek Jemielity,

Published in Organic and Biomolecular Chemistry 16 (2018) 6741-6748

Exploring the potential of phosphotriazole 5′ mRNA cap analogues as efficient translation initiators


ExciTides: NTP-derived probes for monitoring pyrophosphatase activity based on excimer-to-monomer transitions

By Przemysław Wanat, Renata Kasprzyk, Michał Kopciał, Paweł J. Sikorski, Dominika Strzelecka, Jacek Jemielity, Joanna Kowalska,

Published in Chemical Communications 54 (2018) 9773-9776

ExciTides: NTP-derived probes for monitoring pyrophosphatase activity based on excimer-to-monomer transitions


5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes

By Błażej A. Wojtczak, Paweł J. Sikorski, Kaja Fac-Dąbrowska, Anna Nowicka, Marcin Warmiński, Dorota Kubacka, Elżbieta Nowak, Marcin Nowotny, Joanna Kowalska, Jacek Jemielity,

Published in Journal of the American Chemical Society 140 (2018) 5987-5999

5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes


Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis

By JS Mugridge, RW Tibble, M Ziemniak, J Jemielity, JD Gross,

Published in Nature communications 9 (2018) 1152

Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis


7-Methylguanosine monophosphate analogues with 5′-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase

By Mateusz Kozarski, Dorota Kubacka, Błażej A. Wojtczak, Renata Kasprzyk, Marek Baranowski, Joanna Kowalska,

Published in Bioorganic & Medicinal Chemistry 26 (2018) 191-199

7-Methylguanosine monophosphate analogues with 5′-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase


Azido-Functionalized 5ʹ-Cap Analogs for Preparation of Translationally Active mRNAs Suitable for Fluorescent Labeling in Living Cells

By Adam Mamot, Pawel J. Sikorski, Marcin Warminski, Joanna Kowalska, Jacek Jemielity,

Published in Angewandte Chemie International Edition 56 (2017) 10.1002/anie.201709052

Azido-Functionalized 5ʹ-Cap Analogs for Preparation of Translationally Active mRNAs Suitable for Fluorescent Labeling in Living Cells


Analysis of mononucleotides by tandem mass spectrometry: investigation of fragmentation pathways for phosphate- and ribose-modified nucleotide analogues

By Dominika Strzelecka, Sebastian Chmielinski, Sylwia Bednarek, Jacek Jemielity, Joanna Kowalska,

Published in Scientific Reports 7 (2017) 8931

Analysis of mononucleotides by tandem mass spectrometry: investigation of fragmentation pathways for phosphate- and ribose-modified nucleotide analogues


mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation

By Anna M. Rydzik, Marcin Warminski, Pawel J. Sikorski, Marek R. Baranowski, Sylwia Walczak, Joanna Kowalska, Joanna Zuberek, Maciej Lukaszewicz, Elzbieta Nowak, Timothy D. W. Claridge, Edward Darzynkiewicz, Marcin Nowotny, Jacek Jemielity,

Published in Nucleic Acids Research 45 (2017) DOI: https://doi.org/10.1093/nar/gkx569

mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation


Synthesis of RNA 5′-Azides from 2′-O-Pivaloyloxymethyl-Protected RNAs and Their Reactivity in Azide–Alkyne Cycloaddition Reactions

By Marcin Warminski, Joanna Kowalska, Jacek Jemielity,

Published in Organic Letters 19 (2017) 3624–3627

Synthesis of RNA 5′-Azides from 2′-O-Pivaloyloxymethyl-Protected RNAs and Their Reactivity in Azide–Alkyne Cycloaddition Reactions