Publications Archive


Analysis of mononucleotides by tandem mass spectrometry: investigation of fragmentation pathways for phosphate- and ribose-modified nucleotide analogues

By Dominika Strzelecka, Sebastian Chmieleinski, Sylwia Bednarek, Jacek Jemielity, Joanna Kowalska,

Published in Scientific Reports 7 (2017) 8931

Analysis of mononucleotides by tandem mass spectrometry: investigation of fragmentation pathways for phosphate- and ribose-modified nucleotide analogues


mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation

By Anna M. Rydzik, Marcin Warminski, Pawel J. Sikorski, Marek R. Baranowski, Sylwia Walczak, Joanna Kowalska, Joanna Zuberek, Maciej Lukaszewicz, Elzbieta Nowak, Timothy D. W. Claridge, Edward Darzynkiewicz, Marcin Nowotny, Jacek Jemielity,

Published in Nucleic Acids Research 45 (2017) DOI: https://doi.org/10.1093/nar/gkx569

mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation


Synthesis of RNA 5′-Azides from 2′-O-Pivaloyloxymethyl-Protected RNAs and Their Reactivity in Azide–Alkyne Cycloaddition Reactions

By Marcin Warminski, Joanna Kowalska, Jacek Jemielity,

Published in Organic Letters 19 (2017) 3624–3627

Synthesis of RNA 5′-Azides from 2′-O-Pivaloyloxymethyl-Protected RNAs and Their Reactivity in Azide–Alkyne Cycloaddition Reactions


Amino-functionalized 5’ cap analogs as tools for site-specific sequence-independent labeling of messenger RNA

By Marcin Warminski, Pawel J Sikorski, Zofia Warminska, Maciej Lukaszewicz, Anna Kropiwnicka, Joanna Zuberek, Edward Darzynkiewicz, Joanna Kowalska, Jacek Jemielity,

Published in Bioconjugate Chemistry 28 (2017) DOI: 10.1021/acs.bioconjchem.7b00291

Amino-functionalized 5’ cap analogs as tools for site-specific sequence-independent labeling of messenger RNA


eIF4E phosphorylation by MST1 reduces translation of a subset of mRNAs, but increases lncRNA translation

By Kyung-Won Min, Sylvia Davila, Richard W. Zealy, Lawson T. Lloyd, In Young Lee, Rumi Lee, Kyung Hye Roh, Ahjin Jung, Jacek Jemielity, Eui-Ju Choi, Je-Hyun Yoon,

Published in Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1860 (2017) 761–772

Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses

By Barbara Kroczynska, Gavin T. Blyth, Robert L. Rafidi, Beata Majchrzak-Kita, Lucy Xu, Diana Saleiro, Ewa M. Kosciuczuk, Jacek Jemielity, Bing Su, Jessica K. Altman, Elizabeth A. Eklund, Eleanor N. Fish, Leonidas C. Platanias,

Published in J. Biol. Chem. 292 (2017) 4743-4752

Applications of Phosphate Modification and Labeling to Study (m)RNA Caps

By Marcin Warminski, Pawel J. Sikorski, Joanna Kowalska, Jacek Jemielity,

Published in Topics in Current Chemistry 375 (2017) Art no. 16

Applications of Phosphate Modification and Labeling to Study (m)RNA Caps


A novel route for preparing 5′ cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry

By Sylwia Walczak, Anna Nowicka, Dorota Kubacka, Kaja Fac, Przemyslaw Wanat, Seweryn Mroczek, Joanna Kowalska, Jacek Jemielity,

Published in Chemical Science 8 (2017) 260 - 267

A novel route for preparing 5′ cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry


Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential

By Malwina Strenkowska, Renata Grzela, Maciej Majewski, Katarzyna Wnek, Joanna Kowalska, Maciej Lukaszewicz, Joanna Zuberek, Edward Darzynkiewicz, Andreas N Kuhn, Ugur Sahin, Jacek Jemielity,

Published in Nucleic Acids Research 44 (2016) 9578-9590

Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential


Structural basis of mRNA-cap recognition by Dcp1–Dcp2

By Jeffrey S. Mugridge, Marcin Ziemniak, Jacek Jemielity, John D. Gross,

Published in Nature Structural & Molecular Biology 23 (2016) 987–994

Structural basis of mRNA-cap recognition by Dcp1–Dcp2