Publications Archive


5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes

By Błażej A. Wojtczak, Paweł J. Sikorski, Kaja Fac-Dąbrowska, Anna Nowicka, Marcin Warmiński, Dorota Kubacka, Elżbieta Nowak, Marcin Nowotny, Joanna Kowalska, Jacek Jemielity,

Published in Journal of the American Chemical Society 140 (2018) 5987-5999

5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes


Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis

By JS Mugridge, RW Tibble, M Ziemniak, J Jemielity, JD Gross,

Published in Nature communications 9 (2018) 1152

Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis


7-Methylguanosine monophosphate analogues with 5′-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase

By Mateusz Kozarski, Dorota Kubacka, Błażej A. Wojtczak, Renata Kasprzyk, Marek Baranowski, Joanna Kowalska,

Published in Bioorganic & Medicinal Chemistry 26 (2018) 191-199

7-Methylguanosine monophosphate analogues with 5′-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase


Azido-Functionalized 5ʹ-Cap Analogs for Preparation of Translationally Active mRNAs Suitable for Fluorescent Labeling in Living Cells

By Adam Mamot, Pawel J. Sikorski, Marcin Warminski, Joanna Kowalska, Jacek Jemielity,

Published in Angewandte Chemie International Edition 56 (2017) 10.1002/anie.201709052

Analysis of mononucleotides by tandem mass spectrometry: investigation of fragmentation pathways for phosphate- and ribose-modified nucleotide analogues

By Dominika Strzelecka, Sebastian Chmielinski, Sylwia Bednarek, Jacek Jemielity, Joanna Kowalska,

Published in Scientific Reports 7 (2017) 8931

Analysis of mononucleotides by tandem mass spectrometry: investigation of fragmentation pathways for phosphate- and ribose-modified nucleotide analogues


mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation

By Anna M. Rydzik, Marcin Warminski, Pawel J. Sikorski, Marek R. Baranowski, Sylwia Walczak, Joanna Kowalska, Joanna Zuberek, Maciej Lukaszewicz, Elzbieta Nowak, Timothy D. W. Claridge, Edward Darzynkiewicz, Marcin Nowotny, Jacek Jemielity,

Published in Nucleic Acids Research 45 (2017) DOI: https://doi.org/10.1093/nar/gkx569

mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation


Synthesis of RNA 5′-Azides from 2′-O-Pivaloyloxymethyl-Protected RNAs and Their Reactivity in Azide–Alkyne Cycloaddition Reactions

By Marcin Warminski, Joanna Kowalska, Jacek Jemielity,

Published in Organic Letters 19 (2017) 3624–3627

Synthesis of RNA 5′-Azides from 2′-O-Pivaloyloxymethyl-Protected RNAs and Their Reactivity in Azide–Alkyne Cycloaddition Reactions


Amino-functionalized 5’ cap analogs as tools for site-specific sequence-independent labeling of messenger RNA

By Marcin Warminski, Pawel J Sikorski, Zofia Warminska, Maciej Lukaszewicz, Anna Kropiwnicka, Joanna Zuberek, Edward Darzynkiewicz, Joanna Kowalska, Jacek Jemielity,

Published in Bioconjugate Chemistry 28 (2017) DOI: 10.1021/acs.bioconjchem.7b00291

Amino-functionalized 5’ cap analogs as tools for site-specific sequence-independent labeling of messenger RNA


eIF4E phosphorylation by MST1 reduces translation of a subset of mRNAs, but increases lncRNA translation

By Kyung-Won Min, Sylvia Davila, Richard W. Zealy, Lawson T. Lloyd, In Young Lee, Rumi Lee, Kyung Hye Roh, Ahjin Jung, Jacek Jemielity, Eui-Ju Choi, Je-Hyun Yoon,

Published in Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1860 (2017) 761–772

Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses

By Barbara Kroczynska, Gavin T. Blyth, Robert L. Rafidi, Beata Majchrzak-Kita, Lucy Xu, Diana Saleiro, Ewa M. Kosciuczuk, Jacek Jemielity, Bing Su, Jessica K. Altman, Elizabeth A. Eklund, Eleanor N. Fish, Leonidas C. Platanias,

Published in J. Biol. Chem. 292 (2017) 4743-4752