Publications Archive


NAD Analogs in Aid of Chemical Biology and Medicinal Chemistry

By Anais Depaix, Joanna Kowalska,

Published in Molecules 24 (2019)

NAD Analogs in Aid of Chemical Biology and Medicinal Chemistry


N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, Reactivity, and Applications to the Study of Cap-Binding Proteins

By Michał Kopciał, Błażej A. Wojtczak, Renata Kasprzyk, Joanna Kowalska, Jacek Jemielity,

Published in Molecules 24 (2019)

N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, Reactivity, and Applications to the Study of Cap-Binding Proteins


Fluorescent turn-on probes for the development of binding and hydrolytic activity assays for mRNA cap-recognising proteins

By Renata Kasprzyk, Beata Jagoda Starek, Sylwia Ciechanowicz, Dorota Kubacka, Joanna Kowalska, Jacek Jemielity,

Published in Chemistry - A European Journal 25 (2019) 6728-6740

Fluorescent turn-on probes for the development of binding and hydrolytic activity assays for mRNA cap-recognising proteins


Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs

By Agnieszka Młynarska-Cieślak, Anais Depaix, Ewa Grudzień-Nogalska, Paweł J. Sikorski, Marcin Warmiński, Megerditch Kiledjian, Jacek Jemielity, Joanna Kowalska,

Published in Organic Letters 20 (2018) 7650–7655

Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs


mRNAs biotinylated within the 5′ cap and protected against decapping: new tools to capture RNA–protein complexes

By Sylwia Bednarek, Vanesa Madan, Paweł J. Sikorski, Ralf Bartenschlager, Joanna Kowalska, Jacek Jemielity,

Published in Philosophical Transactions of The Royal Society B 373 (2018)

mRNAs biotinylated within the 5′ cap and protected against decapping: new tools to capture RNA–protein complexes


Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation

By Katharina Essig, Nina Kronbeck, Joao C. Guimaraes, Claudia Lohs, Andreas Schlundt, Anne Hoffmann, Gesine Behrens, Sven Brenner, Joanna Kowalska, Cristina Lopez-Rodriguez, Jacek Jemielity, Helmut Holtmann, Kristin Reiche, Jörg Hackermüller, Michael Sattler, Mihaela Zavolan , Vigo Heissmeyer,

Published in Nature Communications 9 (2018) 3810

Exploring the potential of phosphotriazole 5′ mRNA cap analogues as efficient translation initiators

By Sylwia Walczak, Paweł Sikorski, Renata Kasprzyk, Joanna Kowalska, Jacek Jemielity,

Published in Organic and Biomolecular Chemistry 16 (2018) 6741-6748

Exploring the potential of phosphotriazole 5′ mRNA cap analogues as efficient translation initiators


ExciTides: NTP-derived probes for monitoring pyrophosphatase activity based on excimer-to-monomer transitions

By Przemysław Wanat, Renata Kasprzyk, Michał Kopciał, Paweł J. Sikorski, Dominika Strzelecka, Jacek Jemielity, Joanna Kowalska,

Published in Chemical Communications 54 (2018) 9773-9776

ExciTides: NTP-derived probes for monitoring pyrophosphatase activity based on excimer-to-monomer transitions


5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes

By Błażej A. Wojtczak, Paweł J. Sikorski, Kaja Fac-Dąbrowska, Anna Nowicka, Marcin Warmiński, Dorota Kubacka, Elżbieta Nowak, Marcin Nowotny, Joanna Kowalska, Jacek Jemielity,

Published in Journal of the American Chemical Society 140 (2018) 5987-5999

5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes


Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis

By JS Mugridge, RW Tibble, M Ziemniak, J Jemielity, JD Gross,

Published in Nature communications 9 (2018) 1152

Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis