Publications Archive


Tricks and threats of RNA viruses – towards understanding the fate of viral RNA

By Łukasz Markiewicz, Karolina Drążkowska, Paweł J. Sikorski,

Published in RNA Biology (2021)

Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect

By Marcin Warmiński, Joanna Kowalska, Elżbieta Nowak, Dorota Kubacka, Ryan Tibble, Renata Kasprzyk, Paweł J. Sikorski, John D. Gross, Marcin Nowotny, Jacek Jemielity,

Published in ACS Chemical Biology 16 (2021) 334–343

Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect


Phosphodiester modifications in mRNA polyA tail prevent deadenylation without compromising protein expression

By Dominika Strzelecka, Mirosław Śmietański, Paweł J. Sikorski, Marcin Warmiński, Joanna Kowalska, Jacek Jemielity,

Published in RNA 26 (2020) 1815-1837

Phosphodiester modifications in mRNA polyA tail prevent deadenylation without compromising protein expression


5′-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR

By Marek R. Baranowski, Marcin Warmiński, Jacek Jemielity, Joanna Kowalska,

Published in Nucleic Acids Research 48 (2020) 8209–8224

5′-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR


DXO/Rai1 enzymes remove 5′-end FAD and dephospho-CoA caps on RNAs

By Selom K. Doamekpor, Ewa Grudzień-Nogalska, Agnieszka Młynarska-Cieślak, Joanna Kowalska, Megerditch Kiledjian, Liang Tong,

Published in Nucleic Acids Research 48 (2020) 6136–6148

DXO/Rai1 enzymes remove 5′-end FAD and dephospho-CoA caps on RNAs


Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation

By Sebastian Gołojuch, Michał Kopciał, Dominika Strzelecka, Renata Kasprzyk, Natalia Baran, Paweł J. Sikorski, Joanna Kowalska, Jacek Jemielity,

Published in Bioorganic & Medicinal Chemistry 28 (2020) 115523

Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation


Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity

By Renata Kasprzyk, Mateusz Fido, Adam Mamot, Przemysław Wanat, Mirosław Śmietański, Michał Kopciał, Victoria Cowling, Joanna Kowalska, Jacek Jemielity,

Published in Chemistry - A European Journal 26 (2020) 11266 11275

Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity


Synthesis of trifluoromethylated purine ribonucleotides and their evaluation as 19F NMR probes

By Mikołaj Chromiński, Marek R. Baranowski, Sebastian Chmieliński, Joanna Kowalska, Jacek Jemielity,

Published in The Journal of Organic Chemistry 85 (2020) 3440-3453

Synthesis of trifluoromethylated purine ribonucleotides and their evaluation as 19F NMR probes


The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells

By Paweł J. Sikorski, Marcin Warmiński, Dorota Kubacka, Tomasz Ratajczak, Dominika Nowis, Jonanna Kowalska, Jacek Jemielity,

Published in Nucleic Acids Research 48 (2020) 1607-1626

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells


Purine and pyrimidine dinucleoside polyphosphates differentially affect the phenylpropanoid pathway in Vitis vinifera L. cv. Monastrell suspension cultured cells

By Małgorzata Pietrowska-Borek, Anna Wojdyła-Mamoń, Jędrzej Dobrogojski, Agnieszka Młynarska-Cieślak, Marek R Baranowski, Jakub M. Dąbrowski, Joanna Kowalska, Jacek Jemielity, Sławomir Borek, Maria Angeles Pedreño, Andrzej Guranowski,

Published in Plant Physiology and Biochemistry 147 (2020) 125-132

Purine and pyrimidine dinucleoside polyphosphates differentially affect the phenylpropanoid pathway in Vitis vinifera L. cv. Monastrell suspension cultured cells