Publications Archive


Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5′cap Analogs: Synthesis and Evaluation as Modulators of Translation

By Radosław Wójcik, Marek Baranowski, Łukasz Markiewicz, Kubacka Dorota, Marcelina Bednarczyk, Natalia Baran, Anna Wojtczak, Paweł J. Sikorski, Joanna Żuberek, Joanna Kowalska, Jacek Jemielity,

Published in Pharmaceutics 13 (2021)

Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5′cap Analogs: Synthesis and Evaluation as Modulators of Translation


Reproducible and efficient new method of RNA 3’-end labelling by CutA nucleotidyltransferase-mediated CC-tailing

By Rafał Tomecki, Kamil Kobylecki, Karolina Drążkowska, Malwina Hyjek-Skladanowska, Andrzej Dziembowski,

Published in RNA Biology (2021)

Ethylenediamine derivatives efficiently react with oxidized RNA 3′ ends providing access to mono and dually labelled RNA probes for enzymatic assays and in vivo translation

By Adam Mamot, Paweł J. Sikorski, Aleksandra Siekierska, Peter de Witte, Joanna Kowalska, Jacek Jemielity,

Published in Nucleic Acids Research (2021)

Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase

By Renata Kasprzyk, Tomasz J. Śpiewla, Mirosław Śmietański, Sebastian Gołojuch, Laura Vangeel, Steven De Jonghe, Dirk Jochmans, Johan Neyts, Joanna Kowalska, Jacek Jemielity,

Published in Antiviral Research 193 (2021)

Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase


Nucleotide-decorated AuNPs as probes for nucleotide-binding proteins

By Olga Perzanowska, Maciej Majewski, Malwina Strenkowska, Paulina Głowala, Mariusz Czarnocki-Cieciura, Maciej Mazur, Joanna Kowalska, Jacek Jemielity,

Published in Scientific Reports 11 (2021) 15741

Nucleotide-decorated AuNPs as probes for nucleotide-binding proteins


Enzymatic assays to explore viral mRNA capping machinery

By Renata Kasprzyk, Jacek Jemielity,

Published in ChemBioChem 22 (2021) 1-19

An integrative approach uncovers transcriptome-wide determinants of mRNA stability regulation in Saccharomyces cerevisiae

By Rafał Tomecki, Karolina Drążkowska,

Published in FEBS Journal 288 (2021) 3418-3423

Cellular delivery of dinucleotides by conjugation with small molecules: targeting translation initiation for anticancer applications

By Natalia Kleczewska, Paweł J. Sikorski, Zofia Warmińska, Łukasz Markiewicz, Renata Kasprzyk, Natalia Baran, Karina Kwapiszewska, Aneta Karpińska, Jarosław Michalski, Robert Hołyst, Joanna Kowalska, Jacek Jemielity,

Published in Chemical Science 12 (2021) 10242–10251

Cellular delivery of dinucleotides by conjugation with small molecules: targeting translation initiation for anticancer applications


Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation

By Alison Galloway, Aneesa Kaskar, Dimitrinka Ditsova, Abdelmadjid Atrih, Harunori Yoshikawa, Carolina Gomez-Moreira, Olga Suska, Marcin Warminski, Renata Grzela, Angus I. Lamond, Edward Darzynkiewicz, Jacek Jemielity, Victoria H. Cowling,

Published in Nucleic Acids Research 49 (2021) 6722–6738

Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation


RNA Ligation for Mono and Dually Labeled RNAs

By Anais Depaix, Agnieszka Młynarska-Cieślak, Marcin Warmiński, Paweł J. Sikorski, Jacek Jemielity, Joanna Kowalska,

Published in Chemistry - A European Journal 27 (2021) 12190-12197