Publications Archive


Evaluation of carboxyfluorescein-labeled 7-methylguanine nucleotides as probes for studying cap-binding proteins by fluorescence anisotropy

By Anna Wojtczak, Renata Kasprzyk, Marcin Warmiński, Krystian Ubych, Dorota Kubacka, Paweł J. Sikorski, Jacek Jemielity, Joanna Kowalska,

Published in Scientific Reports 11 (2021) 7687

Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation

By Ryan W. Tibble, Anais Depaix, Joanna Kowalska, Jacek Jemielity, John D. Gross,

Published in Nature Chemical Biology 17 (2021) 615–623

Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation


Tricks and threats of RNA viruses – towards understanding the fate of viral RNA

By Łukasz Markiewicz, Karolina Drążkowska, Paweł J. Sikorski,

Published in RNA Biology 18 (2021) 669–687

Synthesis of Trifluoromethylated Purine Ribonucleotides and Their Evaluation as 19F NMR Probes

By Mikołaj Chromiński, Marek R. Baranowski, Sebastian Chmieliński, Joanna Kowalska, Jacek Jemielity,

Published in Journal of Organic Chemistry 85 (2021) 3440–3453

Synthesis of Trifluoromethylated Purine Ribonucleotides and Their Evaluation as 19F NMR Probes


Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect

By Marcin Warmiński, Joanna Kowalska, Elżbieta Nowak, Dorota Kubacka, Ryan Tibble, Renata Kasprzyk, Paweł J. Sikorski, John D. Gross, Marcin Nowotny, Jacek Jemielity,

Published in ACS Chemical Biology 16 (2021) 334–343

Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect


Phosphodiester modifications in mRNA polyA tail prevent deadenylation without compromising protein expression

By Dominika Strzelecka, Mirosław Śmietański, Paweł J. Sikorski, Marcin Warmiński, Joanna Kowalska, Jacek Jemielity,

Published in RNA 26 (2020) 1815-1837

Phosphodiester modifications in mRNA polyA tail prevent deadenylation without compromising protein expression


Efficient Synthesis of Trifluoromethylated Purine Ribonucleosides and Ribonucleotides

By Mikołaj Chromiński, Joanna Kowalska, Jacek Jemielity,

Published in Current Protocols in Nucleic Acid Chemistry 83 (2020) e118

5′-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR

By Marek R. Baranowski, Marcin Warmiński, Jacek Jemielity, Joanna Kowalska,

Published in Nucleic Acids Research 48 (2020) 8209–8224

5′-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR


DXO/Rai1 enzymes remove 5′-end FAD and dephospho-CoA caps on RNAs

By Selom K. Doamekpor, Ewa Grudzień-Nogalska, Agnieszka Młynarska-Cieślak, Joanna Kowalska, Megerditch Kiledjian, Liang Tong,

Published in Nucleic Acids Research 48 (2020) 6136–6148

DXO/Rai1 enzymes remove 5′-end FAD and dephospho-CoA caps on RNAs


Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation

By Sebastian Gołojuch, Michał Kopciał, Dominika Strzelecka, Renata Kasprzyk, Natalia Baran, Paweł J. Sikorski, Joanna Kowalska, Jacek Jemielity,

Published in Bioorganic & Medicinal Chemistry 28 (2020) 115523

Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation