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Publications Archive for 2012

Synthesis of biotin labelled cap analogue – incorporable into mRNA transcripts and promoting cap-dependent translation

By Jemielity J., Lukaszewicz M., Kowalska J., Czarnecki J., Zuberek J., Darzynkiewicz E.,

Published in Organic & Biomolecular Chemistry 10 (2012) 8570 - 8574

Synthesis of biotin labelled cap analogue – incorporable into mRNA transcripts and promoting cap-dependent translation


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Preparation of Synthetically Challenging Nucleotides Using Cyanoethyl P-Imidazolides and Microwaves

By Strenkowska M., Wanat P., Ziemniak M., Jemielity J., Kowalska J.,

Published in Organic Letters 14 (2012) 4782 - 4785

Preparation of Synthetically Challenging Nucleotides Using Cyanoethyl P-Imidazolides and Microwaves


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Synthesis of nucleoside phosphosulfates

By Kowalska J., Osowniak A., Zuberek J., Jemielity J.,

Published in Bioorganic & Medicinal Chemistry Letters 22 (2012) 3661 - 3664

Synthesis of nucleoside phosphosulfates


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Affinity resins containing enzymatically resistant mRNA cap analogs-a new tool for the analysis of cap-binding proteins

By Szczepaniak S.A., Zuberek J., Darzynkiewicz E., Kufel J., Jemielity J.,

Published in RNA 18 (2012) 1421 - 1432

Affinity resins containing enzymatically resistant mRNA cap analogs-a new tool for the analysis of cap-binding proteins


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Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety – fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis

By Rydzik, A. M., Kulis, M., Lukaszewicz, M., Kowalska, J., Zuberek, J., Darzynkiewicz, Z. M., Darzynkiewicz, E., Jemielity, J.,

Published in Bioorganic and Medicinal Chemistry 20 (2012) 1699 - 1710

Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety – fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis


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7-methylguanosine diphosphate (m7GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity

By Wypijewska A., Bojarska E., Lukaszewicz M., Stepinski J., Jemielity J., Davis R.E, Darzynkiewicz E.,

Published in Biochemistry 51 (2012) 8003 - 8013

7-methylguanosine diphosphate (m7GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity


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