Publications Archive for 2020


DXO/Rai1 enzymes remove 5′-end FAD and dephospho-CoA caps on RNAs

By Selom K. Doamekpor, Ewa Grudzień-Nogalska, Agnieszka Młynarska-Cieślak, Joanna Kowalska, Megerditch Kiledjian, Liang Tong,

Published in Nucleic Acids Research (2020)

DXO/Rai1 enzymes remove 5′-end FAD and dephospho-CoA caps on RNAs


Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation

By Sebastian Gołojuch, Michał Kopciał, Dominika Strzelecka, Renata Kasprzyk, Natalia Baran, Paweł J. Sikorski, Joanna Kowalska, Jacek Jemielity,

Published in Bioorganic & Medicinal Chemistry (2020)

Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation


Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity

By Renata Kasprzyk, Mateusz Fido, Adam Mamot, Przemysław Wanat, Mirosław Śmietański, Michał Kopciał, Victoria Cowling, Joanna Kowalska, Jacek Jemielity,

Published in Chemistry - A European Journal (2020)

Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity


Synthesis of trifluoromethylated purine ribonucleotides and their evaluation as 19F NMR probes

By Mikołaj Chromiński, Marek R. Baranowski, Sebastian Chmieliński, Joanna Kowalska, Jacek Jemielity,

Published in The Journal of Organic Chemistry 85 (2020) 3440-3453

Synthesis of trifluoromethylated purine ribonucleotides and their evaluation as 19F NMR probes


The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells

By Paweł J. Sikorski, Marcin Warmiński, Dorota Kubacka, Tomasz Ratajczak, Dominika Nowis, Jonanna Kowalska, Jacek Jemielity,

Published in Nucleic Acids Research 48 (2020) 1607-1626

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells


Purine and pyrimidine dinucleoside polyphosphates differentially affect the phenylpropanoid pathway in Vitis vinifera L. cv. Monastrell suspension cultured cells

By Małgorzata Pietrowska-Borek, Anna Wojdyła-Mamoń, Jędrzej Dobrogojski, Agnieszka Młynarska-Cieślak, Marek R Baranowski, Jakub M. Dąbrowski, Joanna Kowalska, Jacek Jemielity, Sławomir Borek, Maria Angeles Pedreño, Andrzej Guranowski,

Published in Plant Physiology and Biochemistry 147 (2020) 125-132

Purine and pyrimidine dinucleoside polyphosphates differentially affect the phenylpropanoid pathway in Vitis vinifera L. cv. Monastrell suspension cultured cells


Kinetic Analysis of IFIT1 and IFIT5 Interactions With Different Native and Engineered RNAs and Its Consequences for Designing mRNA-based Therapeutics

By Beata Miedziak, Anna Dobieżyńska, Zbigniew M. Darżynkiewicz, Julia Bartkowska, Joanna Miszkiewicz, Joanna Kowalska, Marcin Warmiński, Michał Tyras, Joanna Trylska, Jacek Jemielity, Edward Darźynkiewicz, Renata Grzela,

Published in RNA 26 (2020) 58-68