Publications Archive


Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity

By Renata Kasprzyk, Mateusz Fido, Adam Mamot, Przemysław Wanat, Mirosław Śmietański, Michał Kopciał, Victoria Cowling, Joanna Kowalska, Jacek Jemielity,

Published in Chemistry - A European Journal 26 (2020) 11266 11275

Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity


Synthesis of trifluoromethylated purine ribonucleotides and their evaluation as 19F NMR probes

By Mikołaj Chromiński, Marek R. Baranowski, Sebastian Chmieliński, Joanna Kowalska, Jacek Jemielity,

Published in The Journal of Organic Chemistry 85 (2020) 3440-3453

Synthesis of trifluoromethylated purine ribonucleotides and their evaluation as 19F NMR probes


The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells

By Paweł J. Sikorski, Marcin Warmiński, Dorota Kubacka, Tomasz Ratajczak, Dominika Nowis, Jonanna Kowalska, Jacek Jemielity,

Published in Nucleic Acids Research 48 (2020) 1607-1626

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells


Purine and pyrimidine dinucleoside polyphosphates differentially affect the phenylpropanoid pathway in Vitis vinifera L. cv. Monastrell suspension cultured cells

By Małgorzata Pietrowska-Borek, Anna Wojdyła-Mamoń, Jędrzej Dobrogojski, Agnieszka Młynarska-Cieślak, Marek R Baranowski, Jakub M. Dąbrowski, Joanna Kowalska, Jacek Jemielity, Sławomir Borek, Maria Angeles Pedreño, Andrzej Guranowski,

Published in Plant Physiology and Biochemistry 147 (2020) 125-132

Purine and pyrimidine dinucleoside polyphosphates differentially affect the phenylpropanoid pathway in Vitis vinifera L. cv. Monastrell suspension cultured cells


Kinetic Analysis of IFIT1 and IFIT5 Interactions With Different Native and Engineered RNAs and Its Consequences for Designing mRNA-based Therapeutics

By Beata Miedziak, Anna Dobieżyńska, Zbigniew M. Darżynkiewicz, Julia Bartkowska, Joanna Miszkiewicz, Joanna Kowalska, Marcin Warmiński, Michał Tyras, Joanna Trylska, Jacek Jemielity, Edward Darźynkiewicz, Renata Grzela,

Published in RNA 26 (2020) 58-68

NAD Analogs in Aid of Chemical Biology and Medicinal Chemistry

By Anais Depaix, Joanna Kowalska,

Published in Molecules 24 (2019)

NAD Analogs in Aid of Chemical Biology and Medicinal Chemistry


N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, Reactivity, and Applications to the Study of Cap-Binding Proteins

By Michał Kopciał, Błażej A. Wojtczak, Renata Kasprzyk, Joanna Kowalska, Jacek Jemielity,

Published in Molecules 24 (2019)

N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, Reactivity, and Applications to the Study of Cap-Binding Proteins


Fluorescent turn-on probes for the development of binding and hydrolytic activity assays for mRNA cap-recognising proteins

By Renata Kasprzyk, Beata Jagoda Starek, Sylwia Ciechanowicz, Dorota Kubacka, Joanna Kowalska, Jacek Jemielity,

Published in Chemistry - A European Journal 25 (2019) 6728-6740

Fluorescent turn-on probes for the development of binding and hydrolytic activity assays for mRNA cap-recognising proteins


Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs

By Agnieszka Młynarska-Cieślak, Anais Depaix, Ewa Grudzień-Nogalska, Paweł J. Sikorski, Marcin Warmiński, Megerditch Kiledjian, Jacek Jemielity, Joanna Kowalska,

Published in Organic Letters 20 (2018) 7650–7655

Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs


mRNAs biotinylated within the 5′ cap and protected against decapping: new tools to capture RNA–protein complexes

By Sylwia Bednarek, Vanesa Madan, Paweł J. Sikorski, Ralf Bartenschlager, Joanna Kowalska, Jacek Jemielity,

Published in Philosophical Transactions of The Royal Society B 373 (2018)

mRNAs biotinylated within the 5′ cap and protected against decapping: new tools to capture RNA–protein complexes