Publications Archive


Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential

By Malwina Strenkowska, Renata Grzela, Maciej Majewski, Katarzyna Wnek, Joanna Kowalska, Maciej Lukaszewicz, Joanna Zuberek, Edward Darzynkiewicz, Andreas N Kuhn, Ugur Sahin, Jacek Jemielity,

Published in Nucleic Acids Research 44 (2016) 9578-9590

Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential


Structural basis of mRNA-cap recognition by Dcp1–Dcp2

By Jeffrey S. Mugridge, Marcin Ziemniak, Jacek Jemielity, John D. Gross,

Published in Nature Structural & Molecular Biology 23 (2016) 987–994

Structural basis of mRNA-cap recognition by Dcp1–Dcp2


Synthetic Capped mRNAs for Cap-Specific Photo-Cross-Linking Experiments

By Joanna Kowalska, Franck Martin, Jacek Jemielity,

Published in Methods in Molecular Biology 1428 (2016) 31-43

Synthetic m3G-CAP attachment necessitates a minimum trinucleotide constituent to be recognised as a Nuclear Import Signal

By Malgorzata Honcharenko, Burcu Bestas, Martina Jezowska, Blazej A Wojtczak, Pedro Moreno, Joanna Romanowska, Susanna M Bächle, Edward Darzynkiewicz, Jacek Jemielity, C. I. Edvard Smith, Roger Stromberg,

Published in RSC Advances 6 (2016) 51367-51373

Synthetic m3G-CAP attachment necessitates a minimum trinucleotide constituent to be recognised as a Nuclear Import Signal


Fluorescent HTS assay for phosphohydrolases based on nucleoside 5ʹ-fluorophosphates: application in screening for inhibitors of mRNA Decapping Scavenger and PDE-I

By Marek R. Baranowski, Anna Nowicka, Jacek Jemielity, Joanna Kowalska,

Published in Organic & Biomolecular Chemistry 14 (2016) 4595-4604

Fluorescent HTS assay for phosphohydrolases based on nucleoside 5ʹ-fluorophosphates: application in screening for inhibitors of mRNA Decapping Scavenger and PDE-I


Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to Decapping Scavenger activity monitoring

By Renata Kasprzyk, Joanna Kowalska, Zbigniew Wieczorek, Mariusz Szabelski, Ryszard Stolarski, Jacek Jemielity,

Published in Organic & Biomolecular Chemistry 14 (2016) 3863-3868

Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to Decapping Scavenger activity monitoring


Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex

By Marcin Ziemniak, Jeffrey S. Mugridge, Joanna Kowalska, Robert E. Rhoads, John D. Gross, Jacek Jemielity,

Published in RNA 22 (2016) 518-529

Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex


Clickable trimethylguanosine cap analogs modified within the triphosphate bridge: synthesis, conjugation to RNA and susceptibility to degradation

By Blazej A. Wojtczak, Marcin Warminski, Joanna Kowalska, Maciej Lukaszewicz, Malgorzata Honcharenko, C. I. Edvard Smith, Roger Stromberg, Edward Darzynkiewicz, Jacek Jemielity,

Published in RSC Advances 6 (2016) 8317-8328

Clickable trimethylguanosine cap analogs modified within the triphosphate bridge: synthesis, conjugation to RNA and susceptibility to degradation


Interferon γ (IFNγ)-Signaling via mTORC2 and Regulatory Effects in the Generation of Type II IFN Biological Responses

By Barbara Kroczynska, Robert L. Rafidi, Beata Majchrzak-Kita, Ewa M. Kosciuczuk, Gavin T. Blyth, Jacek Jemielity, Zofia Warminska, Diana Saleiro, Swarna Mehrotra, Ahmet Dirim Arslan, Eleanor N. Fish, Leonidas C. Platanias,

Published in J. Biol. Chem. 291 (2016) 2389–2396

Phosphate-modified analogues of m7GTP and m7Gppppm7G – synthesis and biochemical properties

By Marcin Ziemniak, Joanna Kowalska, Maciej Lukaszewicz, Joanna Zuberek, Katarzyna Wnek, Edward Darzynkiewicz, Jacek Jemielity,

Published in Bioorganic & Medicinal Chemistry 23 (2015) 5369–5381

Phosphate-modified analogues of m7GTP and m7Gppppm7G – synthesis and biochemical properties