Publications Archive


mRNA Cap Modification through Carb­amate Chemistry: Synthesis of Amino- and Carboxy-Functionalised Cap Analogues Suitable for Labelling and Bioconjugation

By Marcin Warminski, Zofia Warminska, Joanna Kowalska, Jacek Jemielity,

Published in European Journal of Organic Chemistry 2015 (2015) 6153–6169

mRNA Cap Modification through Carb­amate Chemistry: Synthesis of Amino- and Carboxy-Functionalised Cap Analogues Suitable for Labelling and Bioconjugation


Ethynyl, 2-Propynyl, and 3-Butynyl C-Phosphonate Analogues of Nucleoside Di- and Triphosphates: Synthesis and Reactivity in CuAAC

By Przemyslaw Wanat, Sylwia Walczak, Blazej A. Wojtczak, Monika Nowakowska, Jacek Jemielity, Joanna Kowalska,

Published in Organic Letters 17 (2015) 3062-3065

Ethynyl, 2-Propynyl, and 3-Butynyl C-Phosphonate Analogues of Nucleoside Di- and Triphosphates: Synthesis and Reactivity in CuAAC


Synthesis of Fluorophosphate Nucleotide Analogues and Their Characterization as Tools for 19F NMR Studies

By Marek R. Baranowski, Anna Nowicka, Anna M. Rydzik, Marcin Warmiński, Renata Kasprzyk, Błażej A. Wojtczak, Jacek Wójcik, Timothy D. W. Claridge, Joanna Kowalska, Jacek Jemielity,

Published in The Journal of Organic Chemistry 80 (2015) 3982–3997

Synthesis of Fluorophosphate Nucleotide Analogues and Their Characterization as Tools for 19F NMR Studies


Gold-decorated polymer vessel structures as carriers of mRNA cap analogues

By Krystyna Kijewska, Paulina Głowala, Joanna Kowalska, Jacek Jemielity, Katarzyna Kaczyńska, Katarzyna Janiszewska, Jarosław Stolarski, Gary J. Blanchard, Daria Kępińska, Katarzyna Lubelska, Katarzyna Wiktorska, Marcin Pisarek, Maciej Mazur,

Published in Polymer 57 (2015) 77–87

Gold-decorated polymer vessel structures as carriers of mRNA cap analogues


Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding

By Anna Kropiwnicka, Krzysztof Kuchta, Maciej Lukaszewicz, Joanna Kowalska, Jacek Jemielity, Krzysztof Ginalski, Edward Darzynkiewicz, Joanna Zuberek,

Published in Biochemical and Biophysical Research Communications 456 (2015) 47-52

Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding


Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma

By Monika Zochowska, Anne-Christine Piguet, Jacek Jemielity, Joanna Kowalska, Ewa Szolajska, Jean-Francois Dufour, Jadwiga Chroboczek,

Published in Nanomedicine: Nanotechnology, Biology and Medicine 11 (2015) 67-76

Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma


Towards novel efficient and stable nuclear import signals: synthesis and properties of trimethylguanosine cap analogs modified within the 5’,5’-triphosphate bridge

By Malgorzata Zytek, Joanna Kowalska, Maciej Lukaszewicz, Blazej A. Wojtczak, Joanna Zuberek, Aleksandra Ferenc-Mrozek, Edward Darzynkiewicz, Anna Niedzwiecka, Jacek Jemielity,

Published in Org. Biomol. Chem. 12 (2014) 9184 - 9199

Towards novel efficient and stable nuclear import signals: synthesis and properties of trimethylguanosine cap analogs modified within the 5’,5’-triphosphate bridge


Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

By Joanna Kowalska, Anna Wypijewska del Nogal, Zbigniew M. Darzynkiewicz, Janina Buck, Corina Nicola, Andreas Kuhn, Maciej Lukaszewicz, Joanna Zuberek, Malwina Strenkowska, Marcin Ziemniak, Maciej Maciejczyk, Elzbieta Bojarska, Robert E. Rhoads, Edward Darzynkiewicz, Ugur Sahin, Jacek Jemielity,

Published in Nucleic Acids Research 42 (2014) 10245-10264

Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes


Cap analogs containing 6-thioguanosine – reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules

By Monika Nowakowska, Joanna Kowalska, Franck Martin, Arnaud d'Orchymont, Joanna Zuberek, Maciej Lukaszewicz, Edward Darzynkiewicz, Jacek Jemielity,

Published in Organic & Biomolecular Chemistry 12 (2014) 4841-4847

Cap analogs containing 6-thioguanosine – reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules


Synthesis and evaluation of stability of m3G-CAP analogues in serum-supplemented medium and cytosolic extract

By Malgorzata Honcharenko, Malgorzata Zytek, Burcu Bestas, Pedro Moreno, Jacek Jemielity, Edward Darzynkiewicz, C.I. Edvard Smith, Roger Strömberg,

Published in Bioorganic & Medicinal Chemistry 21 (2013) 7921–7928

Synthesis and evaluation of stability of m3G-CAP analogues in serum-supplemented medium and cytosolic extract