Publications Archive


Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex

By Marcin Ziemniak, Jeffrey S. Mugridge, Joanna Kowalska, Robert E. Rhoads, John D. Gross, Jacek Jemielity,

Published in RNA 22 (2016) 518-529

Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex


Clickable trimethylguanosine cap analogs modified within the triphosphate bridge: synthesis, conjugation to RNA and susceptibility to degradation

By Blazej A. Wojtczak, Marcin Warminski, Joanna Kowalska, Maciej Lukaszewicz, Malgorzata Honcharenko, C. I. Edvard Smith, Roger Stromberg, Edward Darzynkiewicz, Jacek Jemielity,

Published in RSC Advances 6 (2016) 8317-8328

Clickable trimethylguanosine cap analogs modified within the triphosphate bridge: synthesis, conjugation to RNA and susceptibility to degradation


Interferon γ (IFNγ)-Signaling via mTORC2 and Regulatory Effects in the Generation of Type II IFN Biological Responses

By Barbara Kroczynska, Robert L. Rafidi, Beata Majchrzak-Kita, Ewa M. Kosciuczuk, Gavin T. Blyth, Jacek Jemielity, Zofia Warminska, Diana Saleiro, Swarna Mehrotra, Ahmet Dirim Arslan, Eleanor N. Fish, Leonidas C. Platanias,

Published in J. Biol. Chem. 291 (2016) 2389–2396

Phosphate-modified analogues of m7GTP and m7Gppppm7G – synthesis and biochemical properties

By Marcin Ziemniak, Joanna Kowalska, Maciej Lukaszewicz, Joanna Zuberek, Katarzyna Wnek, Edward Darzynkiewicz, Jacek Jemielity,

Published in Bioorganic & Medicinal Chemistry 23 (2015) 5369–5381

Phosphate-modified analogues of m7GTP and m7Gppppm7G – synthesis and biochemical properties


mRNA Cap Modification through Carb­amate Chemistry: Synthesis of Amino- and Carboxy-Functionalised Cap Analogues Suitable for Labelling and Bioconjugation

By Marcin Warminski, Zofia Warminska, Joanna Kowalska, Jacek Jemielity,

Published in European Journal of Organic Chemistry 2015 (2015) 6153–6169

mRNA Cap Modification through Carb­amate Chemistry: Synthesis of Amino- and Carboxy-Functionalised Cap Analogues Suitable for Labelling and Bioconjugation


Ethynyl, 2-Propynyl, and 3-Butynyl C-Phosphonate Analogues of Nucleoside Di- and Triphosphates: Synthesis and Reactivity in CuAAC

By Przemyslaw Wanat, Sylwia Walczak, Blazej A. Wojtczak, Monika Nowakowska, Jacek Jemielity, Joanna Kowalska,

Published in Organic Letters 17 (2015) 3062-3065

Ethynyl, 2-Propynyl, and 3-Butynyl C-Phosphonate Analogues of Nucleoside Di- and Triphosphates: Synthesis and Reactivity in CuAAC


Synthesis of Fluorophosphate Nucleotide Analogues and Their Characterization as Tools for 19F NMR Studies

By Marek R. Baranowski, Anna Nowicka, Anna M. Rydzik, Marcin Warmiński, Renata Kasprzyk, Błażej A. Wojtczak, Jacek Wójcik, Timothy D. W. Claridge, Joanna Kowalska, Jacek Jemielity,

Published in The Journal of Organic Chemistry 80 (2015) 3982–3997

Synthesis of Fluorophosphate Nucleotide Analogues and Their Characterization as Tools for 19F NMR Studies


Gold-decorated polymer vessel structures as carriers of mRNA cap analogues

By Krystyna Kijewska, Paulina Głowala, Joanna Kowalska, Jacek Jemielity, Katarzyna Kaczyńska, Katarzyna Janiszewska, Jarosław Stolarski, Gary J. Blanchard, Daria Kępińska, Katarzyna Lubelska, Katarzyna Wiktorska, Marcin Pisarek, Maciej Mazur,

Published in Polymer 57 (2015) 77–87

Gold-decorated polymer vessel structures as carriers of mRNA cap analogues


Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding

By Anna Kropiwnicka, Krzysztof Kuchta, Maciej Lukaszewicz, Joanna Kowalska, Jacek Jemielity, Krzysztof Ginalski, Edward Darzynkiewicz, Joanna Zuberek,

Published in Biochemical and Biophysical Research Communications 456 (2015) 47-52

Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding


Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma

By Monika Zochowska, Anne-Christine Piguet, Jacek Jemielity, Joanna Kowalska, Ewa Szolajska, Jean-Francois Dufour, Jadwiga Chroboczek,

Published in Nanomedicine: Nanotechnology, Biology and Medicine 11 (2015) 67-76

Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma