mRNA cap analogs for the preparation of chemically engineered mRNAs


 

People involved

Sylwia Bednarek
Kaja Fac
Joanna Kowalska
Monika Nowakowska
Malwina Strenkowska
Zofia Tomasiewicz
Sylwia Walczak
Marcin Warmiński
Marcin Ziemniak

  • Collaborations

Edward Darzynkiewicz 
Robert E. Rhoads
Ugur Sahin

Related publications

The synthesis of isopropylidene mRNA cap analogs modified with phosphorothioate moiety and their evaluation as promoters of mRNA translation, Marcin Warminski, Joanna Kowalska, Janina Buck, Joanna Zuberek, Maciej Lukaszewicz, Corina Nicola, Andreas N. Kuhn ,Ugur Sahin, Edward Darzynkiewicz, Jacek Jemielity, Bioorganic & Medicinal Chemistry Letters 23 (2013) in press (available-on-line)

Synthetic mRNAs with Superior Translation and Stability Properties, Ewa Grudzien-Nogalska, Joanna Kowalska, Wei Su, Andreas N. Kuhn, Sergey V. Slepenkov, Edward Darzynkiewicz, Ugur Sahin, Jacek Jemielity, Robert E. Rhoads, Methods in Molecular Biology 969 (2013) 55-72

mRNAs containing the histone 3′ stem–loop are degraded primarily by decapping mediated by oligouridylation of the 3′ end, Wei Su, Sergey V. Slepenkov, Michael K. Slevin, Shawn M. Lyons, Marcin Ziemniak, Joanna Kowalska, Edward Darzynkiewicz, Jacek Jemielity, William F. Marzluff and Robert E. Rhoads, RNA 19 (2013) 1-16

Synthesis of biotin labelled cap analogue – incorporable into mRNA transcripts and promoting cap-dependent translation, Jemielity J., Lukaszewicz M., Kowalska J., Czarnecki J., Zuberek J., Darzynkiewicz E., Organic & Biomolecular Chemistry 10 (2012) 8570 – 8574